Studium

Humanmedizin an der Universität Freiburg und der University of Massachusetts Medical School
Auslandsaufenthalte am S.G.P.G.I.M.S. Lucknow/Indien, Parkland Memorial Hospital Dal-las/USA; Inselspital Bern/Schweiz; Zentralkrankenhaus Bozen/Italien

Dissertation

Promotion über das Thema “ Podocin und MEC-2 rekrutieren Cholesterin der Plasmamemb-ran zur Organisation von Lipid-Protein-Superkomplexen : Rolle der Palmitoylierung von Po-docin bei der Cholesterin-Rekrutierung“ (2008)

Habilitation

Habilitation für das Fach Innere Medizin an der Medizinischen Fakultät der Universität Köln über das Thema „Molekulare Mechanismen proteinurischer Nierenerkrankungen“ (2018)

Klinische Ausbildung und Tätigkeit

Medizinische Klinik II, Nephrologie und Allgemeine Innere Medizin, Universitätsklinikum Köln
Bereichsleitender Oberarzt Dialyse, Medizinische Klinik II, Universitätsklinikum Köln
Internistische Leitung, Interdisziplinäres Shuntzentrum, Universitätsklinikum Köln

Facharzt für Innere Medizin, Nephrologie, Rheumatologie, Transplantationsmedizin, Not-fallmedizin

Zusatzqualifikationen

ECFMG certificate (US-Lizenz)
ICH/GCP-Training und Zertifikat, Studienleiterkurs; Tätigkeit als Prüfer und Hauptprüfer (Principal Investigator) klinischer Studien

Zusatztätigkeiten/Lehre

Lehrtätigkeit als Privatdozent an der Universitätsklinik Köln
Kommission Shunt/interventionelle Nephrologie der Deutschen Gesellschaft für Nephrologie (DGfN)

Stipendien und Preise

Alumnus der Studienstiftung des deutschen Volkes
Stipendiat der Landesstiftung Baden-Württemberg 2005/2006
Nature Medicine – Award; 9th International Podocyte Conference 2012
Stipendium der Deutschen Gesellschaft für Nephrologie (DGfN) 2014
Bernd-Sterzel Preis – Grundlagenforschung in der Nephrologie (DGfN) 2019
Apherese-Innovationspreis der Deutschen Gesellschaft für Nephrologie (DGfN) 2020

Publikationen

Hagmann H., Khayyat NH., Matin M., Oezel C., Chen H., Schauss A., Schell C., Benzing T., Dryer S., Brinkkoetter PT. Capsazepine (CPZ) Inhibits TRPC6 Conductance and Is Protective in Adriamycin-Induced Nephropathy and Diabetic Glomerulopathy. Cells. 2023 Jan 10;12(2):271.

Hagmann H., Khayyat NH., Oezel C., Papadakis A., Kuczkowski A., Benzing T., Gulbins E., Dryer S., Brinkkoetter PT. Paraoxonase 2 (PON2) Deficiency Reproduces Lipid Alterations of Diabetic and Inflammatory Glomerular Disease and Affects TRPC6 Signaling. Cells. 2022 Nov 16;11(22):3625.

Mukherjee K., Gu C., Collins A., Mettlen M., Samelko B., Altintas MM., Sudhini YR., Wang X., Bouley R., Brown D., Pedro BP., Bane SL., Gupta V., Brinkkoetter PT., Hagmann H., Reiser J., Sever S. Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury. Nat Commun. 2022 May 3;13(1):2422.

Kochanek M., Garcia Borrega J., Beckmann L., Neuhann J., Gathof BS., Di Cristanziano V., Hagmann H. Plasma exchange with COVID-19 convalescent plasma in a patient with severe ANCA-associated vasculitis and COVID-19 pneumonia after rituximab therapy. Clin Kidney J. 2021 May 27;15(1):162-164.

Koehler S., Odenthal J., Ludwig V., Unnersjö Jess D., Höhne M., Jüngst C., Grawe F., Helmstädter M., Janku JL., Bergmann C., Hoyer PF., Hagmann HH., Walz G., Bloch W., Niessen C., Schermer B., Wodarz A., Denholm B., Benzing T., Iden S., Brinkkoetter PT. Scaffold polarity proteins Par3A and Par3B share redundant functions while Par3B acts independent of atypical protein kinase C/Par6 in podocytes to maintain the kidney filtration barrier. Kidney Int. 2022 Apr;101(4):733-751.

Kühne L., Völker LA., Hagmann H., Hägele H., Osterholt T., Eichenauer DA., Thomas A., Breuer J., Grüttner B., Gottschalk I., Kann M., Benzing T., Thevis M., Müller AM., Brinkkoetter PT. First use of the anti-VWF nanobody caplacizumab to treat iTTP in pregnancy. Br J Haematol. 2022 Feb;196(3):e30-e33.

Mangold N., Pippin J., Unnersjoe-Jess D., Koehler S., Shankland S., Brähler S., Schermer B., Benzing T., Brinkkoetter PT., Hagmann H. The Atypical Cyclin-Dependent Kinase 5 (Cdk5) Guards Podocytes from Apoptosis in Glomerular Disease While Being Dispensable for Podocyte Development. Cells. 2021 Sep 18;10(9):2464.

Vogtmann R., Heupel J., Herse F., Matin M., Hagmann H., Bendix I., Kräker K., Dechend R., Winterhager E., Kimmig R., Köninger A., Gellhaus A. Circulating Maternal sFLT1 (Soluble fms-Like Tyrosine Kinase-1) Is Sufficient to Impair Spiral Arterial Remodeling in a Preeclampsia Mouse Model. Hypertension. 2021 Sep;78(4):1067-1079.

Sörgel F., Malin JJ., Hagmann H., Kinzig M., Bilal M., Eichenauer DA., Scherf-Clavel O., Simonis A., El Tabei L., Fuhr U., Rybniker J. (2020) Pharmacokinetics of remdesivir in a COVID-19 patient with end-stage renal disease on intermittent haemodialysis. J Antimicrob Chemother. 2021 Feb 11;76(3):825-827.

Matin M., Mörgelin M., Stetefeld J., Schermer B., Brinkkoetter PT., Benzing T., Koch M., Hagmann H. (2020) Affinity-enhanced multimeric VEGF and PlGF variants for specific adsorption of sFlt-1 to restore angiogenic balance in preeclampsia. Hypertension 2020 Oct;76(4):1176-1184.

Brinkkoetter PT., Bork T., Salou S., Liang W., Mizi A., Özel C., Koehler S., Hagmann H., Ising C., Kuczkowski A., Schnyder S., Abed A., Schermer B., Benzing T., Kretz O., Puelles VG., Lagies S., Schlimpert M., Kammerer B., Handschin C., Schell C., Huber TB. (2019) Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics. Cell Rep. 2019 Apr 30;27(5):1551-1566.

Hagmann H., Brinkkoetter PT. (2018) Experimental Models to Study Podocyte Biology: Stock-Taking the Toolbox of Glomerular Research. Front Pediatr. 2018 Jul 13;6:193.

Adler C., Heller T., Schregel F., Hagmann H., Hellmich M., Adler J., Reuter H. (2018) TIMP-2/IGFBP7 predicts acute kidney injury in out-of-hospital cardiac arrest survivors. Crit Care. 2018 May 12;22(1):126.

Hagmann H., Benzing T., Kurschat C. (2018) Präeklampsie/Eklampsie. Der Nephrologe. 2018 Mar; 13:127–36.

Hagmann H., Mangold N., Rinschen MM., Koenig T., Kunzelmann K., Schermer B., Benzing T., Brinkkoetter PT. (2018) Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression. FASEB J. 2018 Jan;32(1):208-219.

Rinschen MM., Grahammer F., Hoppe AK., Kohli P., Hagmann H., Kretz O., Bertsch S., Höhne M., Göbel H., Bartram MP., Gandhirajan RK., Krüger M., Brinkkoetter PT., Huber TB., Kann M., Wickström SA., Benzing T., Schermer B. (2017) YAP-mediated mechanotransduction determines the podocyte’s response to damage. Sci Signal. 2017 Apr 11;10(474).

Koehler S., Brähler S., Braun F., Hagmann H., Rinschen MM., Späth MR., Höhne M., Wunderlich FT., Schermer B., Benzing T., Brinkkoetter PT. (2017) Construction of a viral T2A-peptide based knock-in mouse model for enhanced Cre recombinase activity and fluorescent labeling of podocytes. Kidney Int. 2017 Jun;91(6):1510-1517.

Hagmann H., Thadhani RI. (2017) Angiogenic Markers in Transition: Thinking Positive. Hypertension. 2017 Apr;69(4):578-579.

Hagmann H., Benzing T., Thadhani RI. (2017) Preeclampsia – from enigmatic syndrome to targeted therapy. Int. Med. Rev. 2017 Jan; 3.

Hagmann H., Oelmann K., Stangl R., Michels G. (2016) Is increased positive end-expiratory pressure the culprit? Autoresuscitation in a 44-year-old man after prolonged cardiopulmonary resuscitation: a case report. J Med Case Rep. 2016 Dec 20;10(1):364.

Koehler S., Brähler S., Kuczkowski A., Binz J., Hackl MJ., Hagmann H., Höhne M., Vogt MC., Wunderlich CM., Wunderlich FT., Schweda F., Schermer B., Benzing T., Brinkkoetter PT. (2016) Single and Transient Ca2+ Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion. Sci Rep. 2016 Oct 19;6:35400.

Ising, C., Bharill, P., Brinkkoetter, S., Brähler, S., Schroeter, C., Koehler, S., Hagmann, H., Merkwirth, C., Höhne, M., Müller, RU., Fabretti, F., Schermer, B., Bloch, W., Kerjaschki, D., Kurschat, CE., Benzing, T., Brinkkoetter, PT. (2016) Prohibitin-2 depletion unravels extra-mitochondrial functions at the kidney filtration barrier. Am J Pathol. 2016 May;186(5):1128-39.

Thadhani, R., Hagmann, H., Schaarschmidt, W., Roth, B., Cingoez, T., Karumanchi, S.A., Wenger, J., Lucchesi, K.J., Tamez, H., Lindner, T., Fridman, A., Thome, U., Kribs, A., Danner, M., Hamacher, S., Mallmann, P., Stepan, H., Benzing, T.(2015) Removal of Soluble Fms-Like Tyrosine Kinase-1 by Dextran Sulfate Apheresis in Preeclampsia. J Am Soc Nephrol. 2016 Mar;27(3):903-13.

Weber, S., Büscher, A.K., Hagmann, H., Liebau, M.C., Heberle, C., Ludwig, M., Rath, S., Alberer, M., Beissert, A., Zenker, M., Hoyer, P.F., Konrad, M., Klein, H.G., Hoefele, J. (2015) Dealing with the incidental finding of secondary variants by the example of SRNS patients undergoing targeted next-generation sequencing. Pediatr Nephrol. 2016 Jan;31(1):73-81.

Hagmann, H., Brinkkoetter, P.T. (2015) ROS and oxidative stress in CKD patients: is it the mitochondria that keeps CKD patients in bed? Nephrol Dial Transplant. 2015 Jun;30(6):867-8.

Ising, C., Koehler, S., Brähler, S., Merkwirth, C., Höhne, M., Baris, O.R., Hagmann, H., Kann, M., Fabretti, F., Dafinger, C., Bloch, W., Schermer, B., Linkermann, A., Brüning, J.C., Kurschat, C.E., Müller, R.U., Wiesner, R.J., Langer, T., Benzing, T., Brinkkoetter, P.T. (2015) Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure. EMBO Mol Med. 7(3):275-87.

Hagmann, H., Taniguchi, Y., Pippin, J.W., Kauerz, H.M., Benzing, T., Shankland, S.J., Brinkkoetter, P.T. (2015) Cyclin I and p35 determine the subcellular distribution of Cdk5. Am J Physiol Cell Physiol. 308(4):C339-47.

Rinschen, M. M., Wu, X., König, T., Pisitkun, T., Hagmann, H., Pahmeyer, C., Lamkemeyer, T., Kohli, P., Schnell, N., Schermer, B., Dryer, S., Brooks, B. R., Beltrao, P., Krueger, M., Brinkkoetter, P. T., and Benzing, T. (2014) Phosphoproteomic Analysis Reveals Regulatory Mechanisms at the Kidney Filtration Barrier. J Am Soc Nephrol. 25(7):1509-22.

Hagmann, H., Bossung, V., Belaidi, A. A., Fridman, A., Karumanchi, S. A., Thadhani, R., Schermer, B., Mallmann, P., Schwarz, G., Benzing, T., and Brinkkoetter, P. T. (2014) Low-molecular weight heparin increases circulating sFlt-1 levels and enhances urinary elimination. PLoS ONE 9, e85258

Hagmann, H., Kuczkowski, A., Ruehl, M., Lamkemeyer, T., Brodesser, S., Horke, S., Dryer, S., Schermer, B., Benzing, T., and Brinkkoetter, P. T. (2014) Breaking the chain at the membrane: paraoxonase 2 counteracts lipid peroxidation at the plasma membrane. FASEB J. 28, 1769–1779.

Kim, E. Y., Anderson, M., Wilson, C., Hagmann, H., Benzing, T., and Dryer, S. E. (2013) NOX2 interacts with podocyte TRPC6 channels and contributes to their activation by diacylglycerol: essential role of podocin in formation of this complex. Am. J. Physiol., Cell Physiol. 305, C960–971.

Anderson, M., Kim, E. Y., Hagmann, H., Benzing, T., and Dryer, S. E. (2013) Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol. Am. J. Physiol., Cell Physiol. 305, C276–289.

Höhne, M., Ising, C., Hagmann, H., Völker, L. A., Brähler, S., Schermer, B., Brinkkoetter, P. T., and Benzing, T. (2013) Light microscopic visualization of podocyte ultrastructure demonstrates oscillating glomerular contractions. Am. J. Pathol. 182, 332–338.

Höpker, K., Hagmann, H., Khurshid, S., Chen, S., Schermer, B., Benzing, T., and Reinhardt, H. C. (2012) Putting the brakes on p53-driven apoptosis. Cell Cycle 11, 4122–4128.

Brähler, S., Ising, C., Hagmann, H., Rasmus, M., Hoehne, M., Kurschat, C., Kisner, T., Goebel, H., Shankland, S., Addicks, K., Thaiss, F., Schermer, B., Pasparakis, M., Benzing, T., and Brinkkoetter, P. T. (2012) Intrinsic proinflammatory signaling in podocytes contributes to podocyte damage and prolonged proteinuria. Am. J. Physiol. Renal Physiol. 303, F1473–1485.

Höpker, K.*, Hagmann, H.*, Khurshid, S., Chen, S., Hasskamp, P., Seeger-Nukpezah, T., Schilberg, K., Heukamp, L., Lamkemeyer, T., Sos, M. L., Thomas, R. K., Lowery, D., Roels, F., Fischer, M., Liebau, M. C., Resch, U., Kisner, T., Röther, F., Bartram, M. P., Müller, R. U., Fabretti, F., Kurschat, P., Schumacher, B., Gaestel, M., Medema, R. H., Yaffe, M. B., Schermer, B., Reinhardt, H. C., and Benzing, T. (2012) AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis. EMBO J. 31, 3961–3975 (*equal contribution)

Ryu, M., Migliorini, A., Miosge, N., Gross, O., Shankland, S., Brinkkoetter, P. T., Hagmann, H., Romagnani, P., Liapis, H., and Anders, H.-J. (2012) Plasma leakage through glomerular basement membrane ruptures triggers the proliferation of parietal epithelial cells and crescent formation in non-inflammatory glomerular injury. J. Pathol. 228(4):482-94.

Hagmann, H., Thadhani, R., Benzing, T., Karumanchi, S. A., and Stepan, H. (2012) The promise of angiogenic markers for the early diagnosis and prediction of preeclampsia. Clin. Chem. 58, 837–845.

Taniguchi, Y., Pippin, J. W., Hagmann, H., Krofft, R. D., Chang, A. M., Zhang, J., Terada, Y., Brinkkoetter, P., and Shankland, S. J. (2012) Both cyclin I and p35 are required for maximal survival benefit of cyclin-dependent kinase 5 in kidney podocytes. AJP: Renal Physiology 302, F1161–F1171.

Thadhani, R., Kisner, T.*, Hagmann, H.*, Bossung, V., Noack, S., Schaarschmidt, W., Jank, A., Kribs, A., Cornely, O. A., Kreyssig, C., Hemphill, L., Rigby, A. C., Khedkar, S., Lindner, T. H., Mallmann, P., Stepan, H., Karumanchi, S. A., and Benzing, T. (2011) Pilot Study of Extracorporeal Removal of Soluble Fms-Like Tyrosine Kinase 1 in Preeclampsia. Circulation 124, 940–950 (*equal contribution)

Huber, T. B., Schermer, B., Müller, R. U., Höhne, M., Bartram, M., Calixto, A., Hagmann, H., Reinhardt, C., Koos, F., Kunzelmann, K., Shirokova, E., Krautwurst, D., Harteneck, C., Simons, M., Pavenstädt, H., Kerjaschki, D., Thiele, C., Walz, G., Chalfie, M., and Benzing, T. (2006) Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proceedings of the National Academy of Sciences 103, 17079–17086.

Book chapter

Hagmann H., Shankland SJ., Brinkkoetter PT. – Cell Cycle and Podocyte Injury. Liu Z-H, He JC (eds): Podocytopathy. Contrib Nephrol. Basel, Karger, 2014, vol 183, pp 12-21